A novel 18F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo



Bioorthogonal covalent labeling with self-labeling enzymes like SNAP-tag bears a high potential for specific targeting of cells for imaging in vitro and also in vivo. To this end, fluorescent SNAP substrates have been established and used in microscopy and fluorescence imaging while radioactive substrates for the highly sensitive and whole-body positron emission tomography (PET) have been lacking. Here, we show for the first time successful and highcontrast PET imaging of subcutaneous SNAP-tag expressing tumor xenografts by bioorthogonal covalent targeting with a novel 18F-based radioligand in vivo.


Depke, Dominic Alexej; Konken, Christian Paul; Rösner, Lukas; Hermann, Sven; Schäfers, Michael; Rentmeister, Andrea

Read the full publication here

Want to stay up to date about the Immune-Image project? Subscribe to our newsletter! сделать дебетовую карту онлайн