news & events
Non-invasive imaging of immune cell activation using a nanobody-based immunotracer targeting human CD69
Tessa De Pauw (VUB) Presentation: “Non-invasive imaging of immune cell activation using a nanobody-based immunotracer targeting human CD69” Focusing on the role of immune activation in disease and therapy, Tessa De Pauw presented her work on a nanobody-based...
Shaping tomorrow’s medicine: The value of patient participation in molecular imaging research
Presenting author: Manou Kooy (PNO) Focusing on the communication and dissemination dimension of the project, Manou Kooy presented work on strategies to enhance visibility and stakeholder engagement within Immune-Image. Her contribution highlights the importance of...
Zr-anti-NKG2D:a new radiopharmaceutical for tracking activated Natural Killer cells
Presenting author: Sofia Rodriguez (VHIR) Sofia Rodriguez brought a translational perspective to the programme, focusing on the application of molecular imaging techniques in clinical research. Her work highlights how imaging can be used to support patient-related...
Pharmacokinetic optimization and de novo design of small-molecule radiotracers targeting
Presenting author: Marek Lakomy (WWU) Taking a biomarker-focused approach, Marek Lakomy presented research on imaging strategies that support the identification and evaluation of immune responses. His work explores how molecular imaging of biomarkers can be used to...
Non-invasive imaging of immune cell activation using a nanobody-based immunotracer targeting human CD69.
Thomas Vogl (WWU) Presentation: Non-invasive imaging of immune cell activation using a nanobody-based immunotracer targeting human CD69. Thomas Vogl presented research focused on molecular imaging applications and their role in understanding immune-related mechanisms....
Follow-up of Immunotherapy Responses by Imaging of CD8+ T-cell Dynamics using a CD8β-targeting Nanobody-based Tracer.
Timo De Groof (VUB) Presentation: Follow-up of Immunotherapy Responses by Imaging of CD8+ T-cell Dynamics using a CD8β-targeting Nanobody-based Tracer. Timo De Groof presented his work on the development of novel tracers targeting immune cells, contributing to...
First evaluation of a S100A8/S100A9-specific nanobody to assess phagocyte-driven inflammatory activity in a murine arthritis model in vivo
Wouter van den Heijden (AUMC) Presentation: First evaluation of a S100A8/S100A9-specific nanobody to assess phagocyte-driven inflammatory activity in a murine arthritis model in vivo With a strong focus on treatment evaluation, Wouter van den Heijden presented...
In vivo evaluation of non-competitive 89Zr-labeled nanobody tracers targeting
Melinda Badenhorst (AUMC) Presentation: In vivo evaluation of non-competitive 89Zr-labeled nanobody tracers targeting Focusing on the clinical application of immune imaging, Melinda Badenhorst presented her work on how molecular imaging techniques can support...
Visualization of phagocyte driven inflammatory activities in vivo by S100A9 specific nanobodies
Presenting author: Sven Hermann (WWU) Sven Hermann presented advanced approaches in molecular imaging aimed at improving the understanding of biological processes at a detailed level. His work focuses on how imaging technologies can be used to study disease...
Non-invasive in vivo monitoring of myeloid cells during the course of acute and chronic T cell dependent cutaneous delayed type hypersensitivity reaction (DTHR) with 64Cu-CD163Nb-PET/MRI
Presenting author: Marc Neumann (EKUT) Focusing on the robustness and reliability of imaging methodologies, Marc Neumann presented work on preclinical imaging and tracer validation. His research emphasises the importance of ensuring that newly developed tracers and...
Zr-CD4-minibody PET reveals inflammation-associated tracer accumulation beyond CD4⁺ T cells
Presenting author: Roman Mehling (EKUT) Roman Mehling’s work explores how molecular imaging can be used to better understand immunological processes in complex disease models. His research focuses on refining imaging approaches that allow for more detailed tracking of...
![Development of a novel Al[18F]F-RESCA labelled CD163-specific PET tracer](https://www.immune-image.eu/wp-content/uploads/2026/04/Marie_Poster-400x250.jpeg)
Development of a novel Al[18F]F-RESCA labelled CD163-specific PET tracer
Presenting author: Marie Velada Dugois (AUMC) Building on the growing need for more precise immune cell imaging tools, Marie Velada Dugois presented her work on the development of a novel Al[18F]F-RESCA-labelled CD163-specific PET tracer. CD163 is associated with...
Poster presentations during the EMIM 2025
During the annual European Molecular Imaging Meeting (EMIM) in Bilbao, seven researchers of the Immune-Image consortium presented their promising research during the poster presentations. In this article, we will give a brief summary of each...
Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors
PAPER Introduction The redirection of T lymphocytes against tumor-associated or tumor-specific antigens, using bispecific antibodies or chimeric antigen receptors (CAR), has shown therapeutic success against certain hematological malignancies. However, this strategy...
Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer
JOURNAL ARTICLE ABSTRACT Immunotherapies have emerged as an effective treatment option for immune-related diseases, such as cancer and inflammatory diseases. However, variations in patient responsiveness limit the broad applicability and success of these...
Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β
PAPER Purpose While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8+ T cell, dynamics could allow early patient...
Interview Nick Devoogdt about the progress within his work package
We interviewed Nick Devoogdt, Professor at Vrije Universiteit Brussel (VUB) and work package leader within Immune-Image, about the recent progress within his work package and the key areas he and his team are concentrating on until the end of the project. He also...
Update from our newly established patient panel
To align Immune-Image procedures with patient needs, a patient panel was set-up based on the preferred design by patients. The patient panel consists of eight individuals, and is divided into an oncology and an inflammatory disease taskforce. More information about...
Interview Lygature: Progress on data storage and analysis enablement
interview Introduction In our latest interview, we had the opportunity to speak with Jan-Willem Boiten, the leader of Work Package 2 (WP2) in the Immune-Image project. Jan-Willem shared exciting insights into the progress and future plans of his work package,...
In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging
JOURNAL ARTICLE Abstract: In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy Increasing evidence emphasizes the pivotal role of CD4+ T cells in orchestrating...
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 831514. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.
