by Daisy van Schaijik | May 8, 2024 | News, Publications
Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET Abstract Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb...
by Daisy van Schaijik | May 8, 2024 | News, Publications
89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs Introduction 89Zr-immuno-PET (positron emission tomography with zirconium-89-labeled monoclonal antibodies ([89Zr]Zr-mAbs)) can be used to study the biodistribution of...
by Anne-Fleur | Mar 26, 2024 | News, Publications
How to obtain the image‑derived blood concentration from 89Zr‑immuno‑PET scans ABSTRACT Background PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is...
by Janneke de Haan | Nov 21, 2023 | News, Publications
Unveiling the potential of a macrophage-targeted PET tracer: A first-in-human study Introduction The human immune system contains a complex network of cells and organs, each with their own unique functions. Within this intricate tapestry, macrophages play an...
by Janneke de Haan | Aug 15, 2023 | Publications
Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I) ABSTRACT Purpose Macrophages play an important role throughout the body. Antiinflammatory macrophages expressing the macrophage mannose...
by Janneke de Haan | Mar 20, 2023 | Publications
Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake ABSTRACT Purpose Positron emission tomography imaging of zirconium-89-labelled monoclonal antibodies (89Zr-Immuno-PET) allows for...
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